Scientist, Membrane Protein Chemistry (Reference ID: SC_PC_02)

The Scientist/ Sr. Scientist, Membrane Protein Chemistry will be a versatile and highly collaborative team player who has a deep understanding of protein chemistry, biophysical characterization, and structural analysis. Hands on experience with purification of integral membrane proteins for structural biology is required but experience purifying GPCRs is preferred. The successful candidate will contribute to our core research capabilities and development of our GPCR platform.

The candidate would support screening and engineering of antibodies to GPCR targets and assist in the biophysical characterization of lead therapeutic candidates. This position represents a unique opportunity for the successful applicant to join an innovative start-up at the heart of the Boston biotech ecosystem and contribute to its long-term success.

About Tectonic Therapeutic:

Tectonic is a privately held biotechnology company that aims to transform the discovery of novel GPCR-targeted drugs and unlock the therapeutic utility of the most challenging receptors in the class. Tectonic’s founders are at the forefront of scientific research in biochemistry and molecular pharmacology with an extensive track record of entrepreneurial achievement.

Professional Responsibilities: 

  • Develop and implement strategies for optimal receptor expression/purification
  • Contribute to target profiles through detailed literature evaluation and experimental characterization of receptors
  • Perform membrane isolation, detergent extraction and purification of GPCRs to be used as antigens in discovery campaigns and functional assays
  • Contribute to development and implementation of new technologies to support the GPCR platform
  • Assist in the design and purification of antibody-based therapeutics that target the desired GPCR function
  • Implement assays for manufacturability assessment leading to clinical candidate selection
  • Contribute to development and execution of assays with techniques such as DSF, ITC, and SPR
  • Maintain a detailed and accurate lab notebook

Position requirements:

  • Ph.D. in Biophysics, Biochemistry, or related discipline with demonstrated track record of scientific achievement in research of multi-pass membrane proteins
  • Experience optimizing membrane protein expression, detergent extraction, purification, and biochemical/biophysical characterization
  • Thorough understanding of the state of the art in GPCR structural biology highly desired
  • Experience with affinity, size-exclusion, and ion exchange purification on AKTA FPLC and analytical chromatography on Agilent HPLC/UPLC desired
  • Proficient communication skills and ability to work both independently and in teams
  • Keen attention to detail and ability to prioritize work on multiple projects, timelines and company goals
  • Desire to quickly learn new skills and adapt to new challenges in a rapidly developing startup environment

Interested applicants may write to with attached cover letter and CV in PDF format. Please include the job reference ID in the subject line.

We are an equal opportunity employer. All applicants will be considered for employment solely on the basis of on business needs, job requirements and individual qualifications, without attention to age, race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.